ToxicologyEmergency MedicineGI / Hepatology
Caustic / Corrosive Ingestion
Strong acid / alkali ingestion — DO NOT induce vomiting, no neutralisation, urgent endoscopy 12–24h, surgical input for full-thickness injury.
Source: TOXBASE; ESPGHAN
Step 1 of ~4
info
Recognise
Common substances:
• Strong alkali (most damaging — liquefactive necrosis): drain cleaners, oven cleaners, bleach, dishwasher tablets, lye.
• Strong acid (coagulative necrosis): toilet bowl cleaners, battery acid, descalers.
• Pediatric ingestion: usually accidental, small volumes.
• Adult ingestion: often intentional, larger volumes, more severe.
Features:
• Oropharyngeal pain, drooling, dysphagia, odynophagia.
• Respiratory: stridor, hoarseness, dyspnoea (laryngeal involvement).
• Abdominal pain, vomiting, haematemesis.
• Mediastinitis / peritonitis if perforation.
Danger levels:
• Alkali pH ≥12: severe injury likely.
• Acid pH ≤2: severe injury likely.
• Disc / button battery — see specific pathway.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Tranexamic Acid (ICU/Trauma/Surgical) · Antifibrinolytic
- Tranexamic Acid (Surgical / Trauma Haemorrhage) · Antifibrinolytic (Haemostatic)
- Tranexamic Acid · Antifibrinolytic — Vascular / Surgical Haemostasis
- Aminocaproic Acid · Antifibrinolytic — Surgical Haemostasis (Alternative to Tranexamic Acid)
- Noradrenaline (Norepinephrine) · Vasopressor (Alpha-1 and Beta-1 Agonist)
- Morphine (IV/IM — Anaesthesia/ICU) · Strong Opioid Analgesic
Pathways
- Paracetamol overdose · TOXBASE/NPIS; MHRA DSU 2012/2024; SNAP regimen (Lancet 2014); BNF
- TCA overdose · TOXBASE/NPIS; AACT/EAPCCT position statements; Resuscitation Council UK ALS
- Opioid overdose · TOXBASE/NPIS; Resuscitation Council UK; BNF
- Anticholinergic toxidrome · TOXBASE/NPIS; AACT/EAPCCT; BNF
- Benzodiazepine overdose · TOXBASE/NPIS; AACT/EAPCCT; BNF
- β-blocker overdose · TOXBASE/NPIS; AACT/EAPCCT; ESC; BNF
Decision support only. Always apply local guidelines and clinical judgement.