Rheumatology
Sjögren's Syndrome
Sicca symptoms + autoantibodies (anti-Ro/La) + Schirmer / salivary gland biopsy — symptomatic + lymphoma surveillance.
Source: ACR/EULAR 2016
Step 1 of ~3
info
Recognise + Workup
Sicca symptoms: dry eyes (gritty, burning, foreign body), dry mouth (difficulty swallowing dry food, water at night, dental caries), parotid enlargement. Extra-glandular: arthralgia / arthritis, Raynaud's, fatigue, neuropathy, ILD, renal tubular acidosis, vasculitis. Increased risk of B-cell lymphoma (~5%).
Bloods: FBC (cytopenias), CRP, ESR (often ↑), RF, ANA, anti-Ro (SSA), anti-La (SSB), complement (C3, C4), serum IgG (often ↑), serum free light chains (lymphoma surveillance).
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Ianalumab (Anti-BAFF — Primary Sjögren's Syndrome) · Anti-BAFF Monoclonal Antibody (B-Cell Survival Factor Inhibitor)
- Obinutuzumab · Anti-CD20 Monoclonal Antibody — CLL / Follicular Lymphoma
- Trimetazidine · Metabolic Anti-Anginal
- Isotretinoin · Systemic retinoid (Vitamin A derivative) / Anti-acne
- Dapsone · Anti-inflammatory / Antimicrobial
- Secukinumab · Anti-IL-17A Monoclonal Antibody
Pathways
- Cutaneous Lupus Erythematosus · BAD; EULAR
- Osteoporosis / Fragility Fracture · NOGG 2021; NICE NG147; NG224
- Arteritic AION (Giant Cell Arteritis) · RCOphth; BSR
- Osteoarthritis Hip / Knee Management · NICE NG226 (2022)
- Lupus Nephritis · EULAR/ERA-EDTA 2019; KDIGO 2024
- Rheumatoid Arthritis Management · NICE CG79 2018 / EULAR 2022
Decision support only. Always apply local guidelines and clinical judgement.