Renal
Renal Transplant Rejection
Recognise acute rejection — biopsy diagnosis (cellular vs antibody-mediated), treatment, infection prophylaxis.
Source: KDIGO 2009 Transplant; BTS 2024
Step 1 of ~6
info
Recognise — Always Discuss with Transplant Centre
Risk patterns: hyperacute (<24h, ABO incompatibility — preventable), accelerated acute (≤7 days), acute (1 week–3 months), chronic (>3 months). Suspect in: ↑ creatinine ≥20% baseline, fever, allograft tenderness, new proteinuria, oliguria. Bloods: creatinine, FBC, CRP, drug levels (tacrolimus / ciclosporin trough), CMV/BKV PCR, donor-specific antibodies (DSA). USS Doppler — exclude vascular thrombosis, RPF obstruction. Always discuss with transplant centre.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Ganciclovir · Antiviral — CMV Treatment (IV) / Retinitis / Transplant
- Atovaquone · Antiparasitic / Antifungal — PCP Prophylaxis / Treatment / Malaria
- Atovaquone with Proguanil Hydrochloride · Antimalarial (Combination — Prophylaxis and Treatment)
- Enoxaparin (VTE in Pregnancy) · Low Molecular Weight Heparin (LMWH) — VTE Prophylaxis/Treatment
- Low Molecular Weight Heparin (Pregnancy VTE) · Anticoagulant — VTE Treatment and Prophylaxis in Pregnancy
- Romosozumab · Anti-Sclerostin Monoclonal Antibody — Anabolic Osteoporosis Treatment
Pathways
- Hyperkalaemia Management · UK Kidney Association Guidelines 2020; NICE CKD Guidelines
- Rhabdomyolysis · Renal Association 2018; UpToDate 2024
- Hypocalcaemia (Adult) · Society for Endocrinology
- SIADH (Endocrine Perspective) · European Hyponatraemia Guidelines 2014
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Acute Kidney Injury (AKI) · KDIGO 2012 / NICE AKI 2019
Decision support only. Always apply local guidelines and clinical judgement.