Renal
Glomerulonephritis Workup
KDIGO 2021 — recognise nephritic syndrome, RPGN red flags, immunology screen, biopsy indications, treatment of pauci-immune / anti-GBM / lupus / IgA / post-infectious.
Source: KDIGO 2021 GN; Renal Association
Step 1 of ~8
info
Recognise Nephritic Syndrome
Haematuria (often with red cell casts, dysmorphic RBCs) + proteinuria (sub-nephrotic) + AKI + hypertension + oedema. Rapidly progressive GN (RPGN) = AKI evolving over days–weeks, often with crescents on biopsy — treat as renal emergency. Bloods: U&E, ACR/PCR, FBC, CRP, complement (C3, C4), ANA, ANCA, anti-GBM, anti-dsDNA, anti-PLA2R, immunoglobulins, ASO/anti-DNase B, hepatitis B/C, HIV, cryoglobulins. Urinalysis + sediment.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Dapsone · Anti-inflammatory / Antimicrobial
- Belimumab (Cutaneous Lupus) · BLyS/BAFF Inhibitor (Anti-B-Lymphocyte Stimulator)
- Aciclovir 800mg Tablets (Ramsay Hunt Syndrome / Herpes Zoster Oticus) · Antiviral — nucleoside analogue (herpes zoster treatment)
- Romosozumab · Anti-Sclerostin Monoclonal Antibody — Anabolic Osteoporosis Treatment
- Ianalumab (Anti-BAFF — Primary Sjögren's Syndrome) · Anti-BAFF Monoclonal Antibody (B-Cell Survival Factor Inhibitor)
- Obinutuzumab (Anti-CD20 — Lupus Nephritis) · Glycoengineered Type II Anti-CD20 Monoclonal Antibody
Pathways
- Hyperkalaemia Management · UK Kidney Association Guidelines 2020; NICE CKD Guidelines
- Rhabdomyolysis · Renal Association 2018; UpToDate 2024
- Hypocalcaemia (Adult) · Society for Endocrinology
- SIADH (Endocrine Perspective) · European Hyponatraemia Guidelines 2014
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Acute Kidney Injury (AKI) · KDIGO 2012 / NICE AKI 2019
Decision support only. Always apply local guidelines and clinical judgement.