Paediatrics
Neonatal Sepsis (Early + Late)
NICE NG195 — early-onset (<72h, GBS / E coli / Listeria) vs late-onset (>72h, CONS / Staph aureus / Gram-negatives), risk factor assessment, antibiotics within 1h.
Source: NICE NG195 (2021); BAPM
Step 1 of ~4
info
Recognise — Subtle Signs
Neonates rarely febrile; signs subtle and non-specific: temperature instability (low or high), poor feeding, vomiting, lethargy, irritability, mottling, apnoea, tachypnoea, grunting, hypoglycaemia, jaundice, seizures, bulging fontanelle. Maintain very low threshold. Verify all neonatal drug doses against BNFc.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Gentamicin (Paediatric) · Aminoglycoside — Neonatal Sepsis / Gram-Negative Infections in Children
- Colistin (Polymyxin E) · Polymyxin — Last-Resort MDR / Carbapenem-Resistant Gram-Negatives
- Fosfomycin · Phosphonic Acid Antibiotic — Uncomplicated UTI / ESBL / MDR Gram-Negatives
- Cefiderocol · Siderophore Cephalosporin (Pan-Drug Resistant Gram-Negatives)
- Andexanet Alfa (Ondexxya) · Factor Xa inhibitor reversal agent
- Prothrombin Complex Concentrate (PCC) · Coagulation Factor Concentrate — Warfarin Reversal
Decision support only. Always apply local guidelines and clinical judgement.