Haematology
Immune Thrombocytopenia (ITP)
Diagnosis of exclusion, treatment by platelet count + bleeding, steroid + IVIG first-line, second-line TPO-RA / rituximab.
Source: ASH 2019; BSH 2018
Step 1 of ~9
info
Diagnose by Exclusion
Isolated thrombocytopenia (platelets <100 × 10⁹/L) with normal Hb, WCC, blood film. EXCLUDE: pseudothrombocytopenia (EDTA clumping — repeat in citrate), drugs (heparin → HIT pathway, quinine, antibiotics), infection (HIV, HCV, H. pylori, EBV, CMV), pregnancy, malignancy (leukaemia, lymphoma, MDS), autoimmune (SLE, antiphospholipid), hypersplenism, MAHA (TTP/HUS — emergency), inherited.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Phenytoin / Fosphenytoin · Antiepileptic — Status Epilepticus (Second-Line)
- Levetiracetam (IV) · Antiepileptic — Status Epilepticus (Second-Line)
- Ethambutol · Antitubercular — First-Line TB (RIPE Regimen, 'E')
- Pyrazinamide · Antitubercular — First-Line TB (RIPE Regimen, 'P')
- Levetiracetam IV (Status Epilepticus) · Antiepileptic — Second-Line Status Epilepticus
- Ethinylestradiol with levonorgestrel · Combined oral contraceptive (2nd-generation progestogen — first-line)
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only. Always apply local guidelines and clinical judgement.