Endocrinology
Cushing's Syndrome Workup
Confirm hypercortisolism (LDDST, urinary cortisol, late-night salivary), distinguish ACTH-dependent vs independent, localise source.
Source: Endocrine Society 2008/2015
Step 1 of ~6
info
Recognise + Initial Screening
Features: central obesity, moon face, buffalo hump, purple striae >1 cm, easy bruising, proximal myopathy, hypertension, diabetes, osteoporosis, mood change, hirsutism, menstrual disturbance. Most common cause: exogenous steroid use (always exclude). Discriminating features (high specificity): plethora, easy bruising, purple striae, proximal myopathy in young patient, atypical osteoporosis.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Dopamine (ICU — Vasopressor/Inotrope) · Catecholamine (Dose-Dependent Vasopressor/Inotrope)
- Dopamine hydrochloride · Inotrope / vasopressor (dose-dependent)
- Retinol palmitate with white soft paraffin, light liquid paraffin, liquid paraffin and wool fat · Ocular lubricant ointment
- Dopamine · Catecholamine vasopressor / inotrope (dose-dependent)
- Ketoconazole (Adrenal Indication) · Adrenal Steroidogenesis Inhibitor (Antifungal with Adrenal Suppressing Properties)
- Tetracosactide · Synthetic ACTH (short Synacthen test)
Pathways
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016
Decision support only. Always apply local guidelines and clinical judgement.