Aminoglycoside antibiotic
Streptomycin
Adult dose
Dose: 15 mg/kg IM/IV OD (max 1g) for TB; specialist
Route: IM/IV
Frequency: OD
Dose adjustments
Renal
Reduce dose / interval per CrCl
Clinical pearls
- MDR-TB, brucellosis, plague, tularaemia — specialist
- Audiometry baseline + during; trough <5 mg/L
Contraindications
- Hypersensitivity
- Pregnancy (ototoxic)
- Myasthenia gravis
- Severe renal impairment
Side effects
- Ototoxicity (vestibular > cochlear)
- Nephrotoxicity
- Neuromuscular blockade
- Rash
- Cytopenias
Interactions
- Loop diuretics
- Other ototoxic/nephrotoxic drugs
- Neuromuscular blockers
Monitoring
- Drug levels
- Audiometry
- U&E
Reference: BNF; NICE NG33; UKHSA; https://bnf.nice.org.uk/drugs/streptomycin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Centor / McIsaac Score for Strep Pharyngitis · Throat
- Ideal Body Weight (Devine) · Anthropometry
- FeverPAIN Score for Strep Throat · Throat
- Jarisch-Herxheimer Reaction Severity Assessment · Treatment Reactions
- PID Severity (CDC Diagnostic Criteria) · Gynaecological Infections
- Gustilo-Anderson Classification (Open Fractures) · Fracture Classification
Drugs
Pathways
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023