Remdesivir

US FDA prescribing information (Veklury, Gilead) §2.1-2.3 - NO UK SPC (eMC) posology was present in this bundle, so this is US labelling and must be verified against the UK SPC. This regimen applies to adults AND paediatric patients weighing at least 40 kg. TREATMENT DURATION - Hospitalised patients: start as soon as possible after diagnosis of symptomatic COVID-19; 10 days total if requiring invasive mechanical ventilation and/or ECMO; 5 days if not requiring invasive mechanical ventilation and/or ECMO, extendable by up to 5 additional days (maximum 10 days total) if the patient does not show clinical improvement. Non-hospitalised patients with mild-to-moderate COVID-19 at high risk of progression to severe disease: 3 days total, started as soon as possible after diagnosis and within 7 days of symptom onset. TESTING: perform hepatic laboratory testing and determine prothrombin time in all patients before starting and while receiving treatment, as clinically appropriate; consider discontinuing if ALT rises above 10 times the upper limit of normal, and discontinue if ALT elevation is accompanied by signs or symptoms of liver inflammation. ADMINISTRATION SETTING: only administer where healthcare providers have immediate access to medications to treat a severe infusion or hypersensitivity reaction such as anaphylaxis; slower infusion rates up to a maximum of 120 minutes may be considered, and patients should be observed for at least one hour after the infusion. ELDERLY: no dosage adjustment required over the age of 65 years.

US FDA prescribing information (Veklury) §2.3, Table 1 - no UK SPC posology in this bundle; verify against the UK SPC and a children's formulary before prescribing. The 5 mg/kg loading / 2.5 mg/kg once-daily maintenance regimen is stated for patients at least 28 days old weighing 3 kg to less than 40 kg. NEONATES less than 28 days old and at least 1.5 kg: 2.5 mg/kg on Day 1, then 1.25 mg/kg once daily from Day 2. CAUTION - the fetched table is flattened and it is NOT unambiguous which loading/maintenance pair the label assigns to patients at least 28 days old weighing 1.5 kg to less than 3 kg; this band must be checked against the full label before use. Treatment durations are the same as for adults.