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Antimalarial combination (DHA-piperaquine)

Piperaquine phosphate with artenimol

Brand names: Eurartesim

Adult dose

Dose: Weight-based once daily for 3 days; e.g. 75–100kg: 4 tabs (320mg/40mg) OD x3
Route: PO
Frequency: OD x 3 days

Clinical pearls

  • Uncomplicated P. falciparum malaria
  • Take on empty stomach — high-fat meal markedly increases absorption and QT effect

Contraindications

  • QT prolongation
  • Severe hepatic impairment
  • Concurrent QT-prolonging drugs
  • First-trimester pregnancy

Side effects

  • QT prolongation
  • Headache
  • Anaemia
  • Eosinophilia
  • Bradycardia
  • Hepatotoxicity

Interactions

  • QT-prolonging drugs
  • Strong CYP3A4 modulators

Monitoring

  • ECG
  • FBC
  • LFTs

Reference: BNF; UKHSA malaria guidance; SmPC; https://bnf.nice.org.uk/drugs/piperaquine-phosphate-with-artenimol/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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