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Siderophore cephalosporin

Cefiderocol

Brand names: Fetcroja

Adult dose

Dose: 2g IV q8h
Route: IV
Frequency: q8h

Clinical pearls

  • NICE TA763 / TA836: limited treatment options for aerobic gram-negative bacilli (CRE, MDR Pseudomonas, Acinetobacter) — restricted to specialist microbiology
  • UKHSA AMR strategy
  • BSAC stewardship

Contraindications

  • Severe beta-lactam hypersensitivity

Side effects

  • Diarrhoea
  • Hypersensitivity
  • C. difficile
  • Hepatic enzyme elevation

Interactions

  • No major identified

Monitoring

  • Renal function
  • C. diff
  • Microbiological response

Reference: BNF; NICE TA763; BSAC; UKHSA AMR; SmPC; https://bnf.nice.org.uk/drugs/cefiderocol/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.