H2-receptor antagonist
Nizatidine
Brand names: Axid
Adult dose
Dose: GORD/PUD: 150–300mg BD or 300mg nocte
Route: PO
Frequency: BD or nocte
Clinical pearls
- GORD/peptic ulcer; PPIs generally preferred
- Less CYP interaction than cimetidine
Contraindications
- Hypersensitivity
Side effects
- Headache
- GI upset
- Sweating
Interactions
- Antacids (reduce absorption)
- Drugs requiring acidic environment for absorption
Reference: BNF; https://bnf.nice.org.uk/drugs/nizatidine/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Lower Gastrointestinal Bleed · BSG 2019; NICE NG141
- Variceal Upper GI Bleed · BSG 2015; Baveno VII (2022)
- Spontaneous Bacterial Peritonitis (SBP) · BSG / EASL 2018
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Hepatic Encephalopathy · EASL 2014; West Haven criteria
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021