Adrenaline (epinephrine)

⚠ SCOPE — THIS DRAFT COVERS THE PAGE'S PRIMARY INDICATION AND ROUTE ONLY: intramuscular adrenaline for anaphylaxis. VERBATIM UK SPC §4.2 (Adults): 'The usual dose is 0.5 mg (0.5ml of adrenaline 1mg/ml (1:1000)).' 'The intramuscular (IM) route is recommended by the EU Resuscitation Council as the most appropriate for most individuals who have to give adrenaline to treat an anaphylactic reaction.' 'The best site for IM injection is the anterolateral aspect of the middle third of the thigh.' 'The subcutaneous route for adrenaline is not recommended for treatment of an anaphylactic reaction as it is less effective.' NOT COVERED BY THIS BUNDLE: (a) the CARDIAC ARREST dose currently shown on the page (1 mg IV every 3–5 min) — neither fetched source contains any cardiac arrest regimen; source it separately before republishing that figure. (b) The NEBULISED route listed on the page. (c) IV/infusion dosing for anaphylaxis — the UK SPC states only that 'Intravenous administration of adrenaline for anaphylaxis requires the use of a 1:10,000 adrenaline solution' and that the IV route 'must be used with extreme caution and is best reserved for specialists familiar with IV use of adrenaline'; it gives no IV dose in the fetched text. DIFFERENT INDICATION, FOR AWARENESS ONLY — the US label in this bundle doses only hypotension associated with septic shock ('Titrate 0.05 mcg/kg/min to 2 mcg/kg/min to achieve desired blood pressure', diluted in 5% dextrose, into a large vein, adjusted every 10 to 15 minutes in increments of 0.05 mcg/kg/min to 0.2 mcg/kg/min, then weaned incrementally, such as by decreasing doses every 30 minutes over a 12- to 24-hour period); that is a different indication, route and product strength (0.1 mg/mL) from this page's primary use and must not be shown as the page dose. maxDose left empty deliberately: no dose ceiling is stated with an explicit maximum cue. Administration by a trained healthcare professional; do not give the 1 mg/ml (1:1000) solution intravenously.

Anaphylaxis only (matching the adult dose above). dosePerKg is null deliberately: the SPC's paediatric regimen is AGE-BANDED with fixed milligram doses, and its only per-kilogram figure (0.01 mg/kg) applies to infants under 6 months ONLY, so it is not valid across the paediatric range and must not drive a weight calculator. VERBATIM §4.2 'Paediatric population — The following doses of Adrenaline (Epinephrine) 1 mg/ml (1:1000) Solution for Injection are recommended: Over 12 years 0.5 mg IM (0.5ml 1mg/ml (1:1000) solution) [0.3 mg IM (0.3ml) if the child is small or pre-pubertal]; 6 - 12 years 0.3 mg IM (0.3ml 1mg/ml (1:1000) solution); 6 months - 6 years 0.15 mg IM (0.15ml 1mg/ml (1:1000) solution); Under 6 months 0.01mg/kg IM (0.01ml/kg 1mg/ml (1:1000) solution). If necessary, these doses may be repeated several times at 5 - 15 minutes intervals according to blood pressure, pulse and respiratory function. A small volume syringe should be used.' concentration = 1 because the source product is adrenaline 1 mg/ml (1:1000) — 1 mg per mL. maxDose left empty deliberately: no explicit maximum-dose cue. DO NOT give this 1:1000 strength intravenously. US label §8.4: 'Safety and effectiveness of epinephrine in pediatric patients with septic shock have not been established.' Verify any under-18 dose against a children's formulary before administration.